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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLCN6 All Species: 14.55
Human Site: T418 Identified Species: 24.62
UniProt: P51797 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51797 NP_001277.1 869 97217 T418 D S F Q L Q V T E D V N S S I
Chimpanzee Pan troglodytes XP_514393 802 89426 T367 T F F C P N D T Y N D M A T L
Rhesus Macaque Macaca mulatta XP_001104721 869 97094 T418 D S F Q L Q V T E D V N S S I
Dog Lupus familis XP_535404 889 99260 S438 S F Q L Q V S S E D V N S S I
Cat Felis silvestris
Mouse Mus musculus O35454 870 96962 S419 S F Q L Q V T S E D V N S T I
Rat Rattus norvegicus P51799 803 88712 Y368 F D S E K M A Y T I H E I P V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516296 878 97865 V430 V H P K P K L V R V L E S L L
Chicken Gallus gallus XP_417644 868 97172 S417 T W S M Q G M S E D V N S S I
Frog Xenopus laevis Q9W701 689 76782 L254 G A F V F R L L A V F N S E Q
Zebra Danio Brachydanio rerio XP_696527 863 96883 N413 T S T Q G S V N E E V N S T I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_396520 803 89642 P368 P Y Q I Y E I P L F M L M G T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001193438 761 83935 L326 V T T L V A F L A A M T M G Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92943 792 87043 N357 N S L H K K G N R V K I I E A
Baker's Yeast Sacchar. cerevisiae P37020 779 87664 I344 V Q E I P I F I A L G I F G G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.2 99.4 93.3 N.A. 96.7 40.8 N.A. 81.3 93.2 22.7 82.6 N.A. N.A. 37.9 N.A. 49.8
Protein Similarity: 100 92.2 99.8 95.1 N.A. 98.7 58 N.A. 85.3 97.8 39.1 90.7 N.A. N.A. 57.3 N.A. 64.6
P-Site Identity: 100 13.3 100 46.6 N.A. 40 0 N.A. 6.6 46.6 20 53.3 N.A. N.A. 0 N.A. 0
P-Site Similarity: 100 40 100 53.3 N.A. 53.3 13.3 N.A. 40 60 40 66.6 N.A. N.A. 20 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 30 22.5 N.A.
Protein Similarity: N.A. N.A. N.A. 48.6 42.1 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 8 8 0 22 8 0 0 8 0 8 % A
% Cys: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 15 8 0 0 0 0 8 0 0 36 8 0 0 0 0 % D
% Glu: 0 0 8 8 0 8 0 0 43 8 0 15 0 15 0 % E
% Phe: 8 22 29 0 8 0 15 0 0 8 8 0 8 0 0 % F
% Gly: 8 0 0 0 8 8 8 0 0 0 8 0 0 22 8 % G
% His: 0 8 0 8 0 0 0 0 0 0 8 0 0 0 0 % H
% Ile: 0 0 0 15 0 8 8 8 0 8 0 15 15 0 43 % I
% Lys: 0 0 0 8 15 15 0 0 0 0 8 0 0 0 0 % K
% Leu: 0 0 8 22 15 0 15 15 8 8 8 8 0 8 15 % L
% Met: 0 0 0 8 0 8 8 0 0 0 15 8 15 0 0 % M
% Asn: 8 0 0 0 0 8 0 15 0 8 0 50 0 0 0 % N
% Pro: 8 0 8 0 22 0 0 8 0 0 0 0 0 8 0 % P
% Gln: 0 8 22 22 22 15 0 0 0 0 0 0 0 0 15 % Q
% Arg: 0 0 0 0 0 8 0 0 15 0 0 0 0 0 0 % R
% Ser: 15 29 15 0 0 8 8 22 0 0 0 0 58 29 0 % S
% Thr: 22 8 15 0 0 0 8 22 8 0 0 8 0 22 8 % T
% Val: 22 0 0 8 8 15 22 8 0 22 43 0 0 0 8 % V
% Trp: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 8 0 0 8 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _